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Very latest GPUs can use their ram as a cache of all CPU RAM so you can render whatever fit in your CPU ram but it something requiring hardware support (and the GTX660 doesn't). This feature works with any software (it is like CPU virtual memory where is the OS doing all the job of swapping on disk the RAM).
Some software directly support "out of core" rendering but it is a very complex (and slow) feature.
P.S. some software claims to support "out of core" rendering but it is just the hardware feature I described.